Non-Ribosomal Peptide Synthetase Substrate Predictor
Non-Ribosomal Peptide Synthetases (NRPSs) are multi-modular enzymes which biosynthesize many important peptide compounds produced by bacteria and fungi. The discovery and characterisation of non-ribosomal peptides are of great interest for the biotechnological industries. We have applied computational mining methods in order to build a database of NRPSs modules which bind to specific substrates. We have used this database to build an HMM predictor of substrates which bind to a given NRPS. The database and the predictor are freely available here.
Implementation scheme
News :
25/10/2011: Database and predictor have been updated.
15/04/2011: Beta tests have been completed.
01/03/2011: The website has been inaugurated.
Links :
- Bioinformatics Service: University of Salamanca
- Hmmer: Biosequence analysis using HMM
- UniProt: Universal Protein Resource
- Pfam: Protein families
- NRPSpredictor2: Specificity prediction of A domains in NRPS
- PKS/NRPS Analysis: Synthase analysis Web-site
- NRPS-PKS: Domain search program for NRPS